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Related Experiment Video

Updated: Apr 13, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Acute and chronic pseudo-obstruction: a current update.

Maria-Pia Bernardi¹, Satish Warrier¹, A Craig Lynch¹

¹Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

ANZ Journal of Surgery

|May 7, 2015

Summary

Acute colonic pseudo-obstruction (ACPO) and chronic intestinal pseudo-obstruction (CIPO) present similar symptoms but have different causes and treatments. This review clarifies their distinct features to improve diagnosis and management, optimizing patient outcomes.

Keywords:

colonic pseudo-obstruction intestinal pseudo-obstruction.

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Area of Science:

Gastroenterology
Colorectal Surgery
Internal Medicine

Background:

Acute colonic pseudo-obstruction (ACPO) and chronic intestinal pseudo-obstruction (CIPO) mimic mechanical bowel obstruction but lack occlusive lesions.
Delayed diagnosis in ACPO and CIPO leads to inappropriate management and adverse patient outcomes.
Understanding the distinct etiologies, including critical illness factors in ACPO and functional motility disorders in CIPO, is crucial.

Purpose of the Study:

To differentiate ACPO and CIPO based on pathophysiology, clinical presentation, and diagnostic features.
To present an updated, safer pharmacological treatment algorithm for ACPO.
To highlight CIPO as a critical differential diagnosis for recurrent abdominal issues and define surgical indications.

Main Methods:

Review of current literature on ACPO and CIPO.
Analysis of pathophysiology, clinical manifestations, and diagnostic modalities.
Synthesis of evidence-based treatment strategies and surgical considerations.

Main Results:

ACPO is often linked to critical illness, while CIPO is a functional motility disorder.
A modified pharmacological algorithm offers a safer treatment approach for ACPO.
Early consideration of CIPO in patients with recurrent abdominal symptoms is essential, with specific criteria for surgical intervention.

Conclusions:

Distinguishing between ACPO and CIPO is vital for appropriate patient management.
Optimized diagnostic and therapeutic strategies, including a revised ACPO treatment algorithm, can improve outcomes.
The surgeon's role in managing these complex conditions, though often a last resort, is significant.