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Enhanced fitness and renal function in Type 2 diabetes
E S Nylen1,2, S M Gandhi1,2, R Kheirbek3
1Department of Endocrinology, Veterans Affairs Medical Center, Washington, DC, USA.
Aims:
To investigate the renal effects of fitness in people with diabetes with mild renal dysfunction.
Methods:
The effect of a 12-week exercise programme on estimated GFR in 128 people with diabetes was evaluated.
Results:
All cardiometabolic variables improved after 12 weeks of supervised exercise. Although there was a modest 3.9% increase in estimated GFR from baseline in the 128 people who completed the study, those with baseline chronic kidney disease stages 2 and 3 were found to have significant (6 and 12%, respectively; p < 0.01) improvements in post-exercise estimated GFR. Moreover, 42% of the people with chronic kidney disease stage 3 improved to chronic kidney disease stage 2 after the intervention.
Conclusion:
Short-term exercise improves renal function in those with more moderate baseline chronic kidney disease. Thus, renal function appears to be responsive to enhanced physical fitness. Being a strong and modifiable risk factor, enhanced fitness should be considered a non-pharmacological adjunct in the management of diabetic kidney disease.
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