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Updated: Apr 13, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Ask about ice, then consider iron.

Antoinette Rabel1, Susan F Leitman2, Jeffery L Miller1

  • 1Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Journal of the American Association of Nurse Practitioners
|May 7, 2015
PubMed
Summary

Ice pica, or pagophagia, is a compulsive craving for ice often linked to iron deficiency. Early screening and iron supplementation are key to effective treatment for at-risk individuals.

Keywords:
Picahemorrhageiron deficiencymenstruationpagophagiapregnancyreview

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Area of Science:

  • Nutritional Science
  • Medical Research
  • Clinical Practice

Background:

  • Pica is an eating disorder characterized by persistent consumption of non-nutritive substances.
  • Ice pica, also known as pagophagia, is a specific form of pica involving the compulsive consumption of ice.

Purpose of the Study:

  • To review the condition of ice pica (pagophagia).
  • To explore the association between ice pica and iron deficiency.
  • To provide recommendations for clinical screening, treatment, and follow-up.

Main Methods:

  • Extensive literature review of scientific publications.
  • Analysis of original research articles, reviews, and clinical practice manuscripts.

Main Results:

  • Ice pica is frequently associated with iron deficiency.
  • Iron supplementation is an effective treatment in most cases.
  • Screening for ice pica can lead to the diagnosis of iron deficiency.

Conclusions:

  • Ice pica is often overlooked in clinical practice.
  • Clinicians should include ice pica screening in the review of systems for at-risk populations.
  • Young women and blood donors are identified as at-risk populations.