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The subjective assessment of cataract
D B Elliott1, J Gilchrist, M Hurst
1University of Bradford Clinical Vision Research Unit, Optometry Department, University of Bradford, UK.
Abstract:
The medical treatment of cataract now appears to be a distinct possibility. A number of anti-cataract formulations are being clinically tested, and more clinical trials are being planned. To obtain a true assessment of a drug's efficacy, a battery of tests are needed which can accurately assess cataract progress. A clinical trial of the proposed anti-cataract drug Bendalina is being conducted. The six subjective methods used to assess cataract progression in the trial are presented. These are refractive error, LogMAR visual acuity, contrast sensitivity, glare sensitivity, retinal visual acuity and displacement threshold hyperacuity. The reasons for using each technique and their method of measurement is explained.
Insights
Medical treatment for cataracts is becoming a reality with new drugs like Bendalina. This study details six subjective tests, including visual acuity and glare sensitivity, to accurately measure cataract progression during clinical trials.
Area of Science:
- Ophthalmology
- Clinical Pharmacology
Background:
- Cataract treatment is evolving, with medical interventions showing promise.
- Several anti-cataract drug formulations are undergoing clinical evaluation.
Purpose of the Study:
- To present six subjective methods for assessing cataract progression in a clinical trial.
- To evaluate the efficacy of the anti-cataract drug Bendalina.
Main Methods:
- Refractive error measurement
- LogMAR visual acuity testing
- Contrast sensitivity assessment
- Glare sensitivity testing
- Retinal visual acuity measurement
- Displacement threshold hyperacuity evaluation
Main Results:
- The study outlines the application and rationale for each of the six subjective assessment techniques.
- Detailed explanations of measurement methodologies are provided for each test.
Conclusions:
- Accurate assessment of cataract progression is crucial for evaluating anti-cataract drug efficacy.
- The presented subjective methods provide a comprehensive approach to monitoring cataract development in clinical trials.
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