Related Experiment Video
Updated: Apr 13, 2026
10:58
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
13.6K
Glioblastoma multiforme: Pathogenesis and treatment
Constantinos Alifieris1, Dimitrios T Trafalis1
1Laboratory of Pharmacology, Medical School, University of Athens, Athens, Greece.
Pharmacology & Therapeutics
|May 7, 2015
Summary
Malignant gliomas (MGs), including glioblastoma multiforme (GBM), have poor prognoses despite aggressive treatments. Research is exploring novel therapies targeting tumor resistance mechanisms for improved outcomes in brain tumor patients.
Area of Science:
- Neuro-oncology
- Cancer Biology
Background:
- Malignant gliomas (MGs) are aggressive primary brain tumors with high mortality.
- Glioblastoma multiforme (GBM) is the most common and lethal type of MG.
- Current treatments offer limited survival benefits, with a median of approximately 15 months.
Purpose of the Study:
- To review current and emerging treatment strategies for malignant gliomas.
- To discuss factors contributing to treatment resistance in MGs.
- To explore future therapeutic perspectives for improved brain tumor control.
Main Methods:
- Comprehensive literature review of recent advancements in MG treatment.
- Analysis of molecular mechanisms underlying glioma pathogenesis and resistance.
- Evaluation of novel therapeutic approaches, including drug delivery, targeted agents, and immunotherapy.
Main Results:
- Treatment resistance in MGs is multifactorial, involving signaling pathways, glioma stem cells, the blood-brain barrier, and MGMT expression.
- Emerging strategies include advanced drug-delivery systems, molecularly targeted therapies, and immunomodulative treatments.
- These novel approaches hold promise for overcoming resistance and improving patient survival.
Conclusions:
- Despite challenges, a deeper understanding of MG biology is driving the development of more effective therapies.
- Future treatment perspectives focus on personalized medicine and combination strategies to enhance efficacy.
- Continued research into tumor resistance mechanisms is crucial for advancing the management of malignant gliomas.
