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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Changes in placental angiogenesis and their correlation with foetal intrauterine restriction

P Bolehovská, B Sehnal, D Driák

    Ceska Gynekologie
    |May 7, 2015
    PubMed

    Insights

    Intrauterine growth restriction (IUGR) affects 3-10% of pregnancies. This review examines how placental vascular development changes impact fetal growth, focusing on angiogenesis in IUGR.

    Area of Science:

    • Obstetrics and Gynecology
    • Fetal Medicine
    • Reproductive Biology

    Background:

    • Intrauterine growth restriction (IUGR) affects 3-10% of pregnancies, often defined by fetal weight below the 10th percentile.
    • Pathological interference with placental vascular development critically impacts fetal growth.
    • Ischemia is a common cause of IUGR, stemming from inadequate capillary loop formation in terminal villi.

    Purpose of the Study:

    • To review current data on placental angiogenesis changes in Intrauterine growth restriction (IUGR).
    • To elucidate the mechanisms of placental vascular supply development under physiological and IUGR conditions.

    Main Methods:

    • This study is a review of existing literature.
    • Focuses on up-to-date data regarding placental angiogenesis and its role in IUGR.

    Main Results:

    • Pathological changes in placental vascular development, particularly ischemia, are strongly linked to IUGR.
    • Insufficient capillary loop formation during villi development is a key factor in IUGR.
    • Understanding these mechanisms is crucial for identifying potential interventions.

    Conclusions:

    • The review summarizes the mechanisms of placental vascularization in both normal and growth-restricted pregnancies.
    • Highlights the critical role of angiogenesis in fetal development and the consequences of its disruption in IUGR.
    Abstract

    Keywords:
    angiogenesis.angiogenic factorsfoetal weightintrauterine growth restrictionplacenta

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