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The spatial learning and memory performance in methamphetamine-sensitized and withdrawn rats.

Imanollah Bigdeli1, Masomeh Nikfarjam-Haft Asia1, Hossein Miladi-Gorji2

  • 1Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran.

Iranian Journal of Basic Medical Sciences
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Summary

Methamphetamine (METH) impairs spatial learning and memory in rats 30 minutes after injection. However, METH effects on spatial memory are time-dependent, with some functions spared at 120 minutes post-injection.

Keywords:
Long -term memoryMETH- sensitized ratsShort -term memorySpatial memory

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Methamphetamine (METH) use is associated with cognitive deficits, but its precise impact on spatial memory remains controversial.
  • Understanding the time-dependent effects of METH on different types of spatial memory is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the time-dependent effects of METH on spatial short-term (working) and long-term (reference) memory in METH-sensitized and withdrawn rats.
  • To assess the persistence of METH-induced memory impairments after prolonged abstinence.

Main Methods:

  • Rats were sensitized to METH and trained in the Morris water maze to assess spatial learning and memory.
  • Working memory was evaluated 30 minutes and 120 minutes after METH administration.
  • Reference memory was assessed after a 30-day withdrawal period.

Main Results:

  • METH-sensitized rats showed impaired spatial learning and working memory 30 minutes post-injection.
  • At 120 minutes post-injection, METH did not affect spatial learning acquisition or working memory but partially impaired reference memory retention.
  • Spatial reference memory deficits persisted even after 30 days of withdrawal.

Conclusions:

  • METH significantly impairs spatial learning and memory in a time-dependent manner in sensitized rats.
  • Spatial working memory is impaired shortly after METH administration, while reference memory deficits persist longer and even after prolonged abstinence.