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Th1 cytokines and chemokines in primary biliary cirrhosis

F Limongi1

  • 1Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

La Clinica Terapeutica
|May 7, 2015
PubMed

Insights

Chemokines like interferon-gamma-induced protein 10 (IP-10) and chemokine (C-X-C motif) ligand 9 (MIG) are involved in primary biliary cirrhosis (PBC) progression. Their levels in the liver and blood decrease with ursodeoxycholic acid (UDCA) treatment.

Area of Science:

  • Immunology
  • Hepatology
  • Molecular Biology

Background:

  • Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by autoimmune destruction of bile ducts.
  • T-helper 1 (Th1) cytokines and chemokines play a role in PBC pathogenesis.
  • The C-X-C motif receptor 3 (CXCR3) and its ligands are implicated in autoimmune cholangitis models.

Purpose of the Study:

  • To investigate the role of CXCR3 chemokines in human PBC.
  • To correlate chemokine expression with disease severity and progression.
  • To assess the effect of ursodeoxycholic acid (UDCA) treatment on chemokine levels.

Main Methods:

  • Analysis of chemokine and CXCR3-positive cell expression in liver biopsies from PBC patients.
  • Measurement of circulating IP-10 and MIG levels in PBC patients and controls.
  • Assessment of chemokine levels before and after UDCA treatment.

Main Results:

  • IP-10 and MIG expression, along with CXCR3-positive cells, were elevated in the portal areas of PBC livers.
  • MIG and IP-10 levels positively correlated with liver fibrosis severity.
  • Circulating IP-10 and MIG levels, and CXCR3-expressing cells, were significantly higher in PBC patients and increased with disease progression.
  • UDCA treatment led to a significant reduction in serum chemokine levels.

Conclusions:

  • CXCR3 chemokines are involved in the pathogenesis and progression of PBC.
  • Elevated chemokine levels are associated with liver fibrosis and disease severity in PBC.
  • UDCA treatment may modulate the inflammatory response in PBC by reducing chemokine levels.

Keywords:
CXCR3ChemokinesCytokinesI-TACIP-10MIGPBC

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