Related Experiment Video

Updated: Aug 19, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Peritonitis caused by meconial ileus in a very premature patient. Presentation of a clinical case]

F Bertuccio1, C Asteria, V Montaldi

  • 1Divisione di Chirurgia Generale, Presidio Ospedaliero di Mantova, Italia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|May 1, 1989
PubMed

Insights

A conservative surgical approach for meconium peritonitis in low birth weight infants with intestinal malrotation involves peritoneal toilette and ileostomy, followed by intensive care and delayed canalization. This method promotes favorable outcomes through multidisciplinary care.

Area of Science:

  • Neonatal Surgery
  • Pediatric Gastroenterology
  • Intestinal Malrotation

Background:

  • Meconium peritonitis is a serious condition in neonates, often linked to intestinal malrotation.
  • Optimal surgical management for this condition remains a subject of clinical interest.

Observation:

  • A case of meconium peritonitis in a low birth weight infant with associated intestinal malrotation was analyzed.
  • The study retrospectively reviewed the surgical approach across different disease stages.

Findings:

  • A conservative surgical strategy, including peritoneal cavity toilette and ileostomy, followed by intensive care, is proposed.
  • Delayed second-look surgery (canalization) after three months, once adequate growth is achieved, is recommended.

Implications:

  • This staged approach allows for careful management of metabolic and nutritional needs.
  • A multidisciplinary team approach is crucial for achieving positive outcomes in these complex cases.
  • This strategy may offer a viable alternative for managing meconium peritonitis in vulnerable infants.

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