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Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

Genome Copying Errors

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their survival. Therefore, the copying errors are checked and repaired at three levels.

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Related Experiment Video

Updated: Apr 13, 2026

Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX

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Correction: A method for multiplex gene synthesis employing error correction based on expression

Timothy H-C Hsiau, David Sukovich, Phillip Elms

|May 7, 2015

Summary

No abstract available in PubMed .

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Last Updated: Apr 13, 2026

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