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Related Concept Videos

Feedback Inhibition

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!

Feedback Loops

Feedback Loops

In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

Internal Receptors

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.

Cross-reactivity

Cross-reactivity

Proofreading

Proofreading

What are Second Messengers?

What are Second Messengers?

Because many receptor binding ligands are hydrophilic, they do not cross the cell membrane and thus their message must be relayed to a second messenger on the inside. There are several second messenger pathways, each with their own way of relaying information. G-protein coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol path is active when the receptor induces phospholipase C to hydrolyze the phospholipid,...

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Related Experiment Video

Updated: Apr 12, 2026

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

The authors reply

Fran Balamuth¹, Scott Weiss, Mark Neuman

¹Division of Emergency Medicine, Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, and Children's Hospital of Philadelphia, PA Department of Anesthesia and Critical Care, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, and Children's Hospital of Philadelphia, PA Department of Pediatrics, Harvard University School of Medicine, Boston, MA Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH Department of Anesthesia and Critical Care, Washington University School of Medicine, St. Louis, MO Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH Children's Hospital of Philadelphia, Philadelphia, PA Department of Emergency Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC Children's Hospital Association, Overland Park, KS Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

|May 7, 2015

Summary

No abstract available in PubMed .

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