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Updated: Apr 12, 2026
Small and Wide Angle X-Ray Scattering Studies of Biological Macromolecules in Solution
Published on: January 8, 2013
Instrumentation on multi-scaled scattering of bio-macromolecular solutions
Benjamin Chu1, Dufei Fang2, Yimin Mao3
1Chemistry Department, Stony Brook University, Stony Brook, New York, NY 11794-3400, USA. Benjamin.chu@stonybrook.edu.
Abstract:
The design, construction and initial tests on a combined laser light scattering and synchrotron X-ray scattering instrument can cover studies of length scales from atomic sizes in Angstroms to microns and dynamics from microseconds to seconds are presented. In addition to static light scattering (SLS), dynamic light scattering (DLS), small angle X-ray scattering (SAXS) and wide angle X-ray diffraction (WAXD), the light scattering instrument is being developed to carry out studies in mildly turbid solutions, in the presence of multiple scattering. Three-dimensional photon cross correlation function (3D-PCCF) measurements have been introduced to couple with synchrotron X-ray scattering to study the structure, size and dynamics of macromolecules in solution.
