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Updated: Apr 12, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
Rapid Osseointegration of Titanium Implant With Innovative Nanoporous Surface Modification: Animal Model and Clinical
Mao-Suan Huang1, Li-Kai Chen, Keng-Liang Ou
1*Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Director, Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, Taipei, Taiwan. †Director, Department of Dentistry, Lo-Hsu Foundation Inc., Lotung Poh-Ai Hospital, Yilan, Taiwan. ‡Chairman, Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan; Chairman, Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan; Dean, Collage of Oral Medicine, Taipei Medical University, Taipei, Taiwan. §Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Researcher, Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan; Researcher, Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan. ‖Director, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Lecturer, School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Objectives:
SLAffinity is the hybrid topography consisting of micropits and nanoporous TiO2 layers through electrochemical oxidation to mimic the natural bony environment. The aim of this study was to examine the rate of osseointegration in animal models and to further investigate the stability for implants with SLAffinity-treated surface in the clinical trial.
Materials And Methods:
Implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received 2 implants with the same shapes but with different chemical surfaces. In the clinical trial, 25 patients were included. Each patient received 1 SLAffinity-treated implant on the posterior area of either arch. Resonance frequency analysis and computed tomography were assessed weekly over the first 12 weeks after implant placement.
Results:
The results found that surface treatment did affect the bone-to-implant contact (BIC) significantly. Comparison of BIC at 3 weeks in animal study showed that the SLAffinity-treated implants presented significantly higher values than machine surface implants. SLAffinity-treated implants also proved clinically successful through 12 months, ready for prosthodontic restoration.
Conclusion:
The effect of SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone healing. Clinical trial finding, furthermore, ensured that the SLAffinity treatment was a reliable surface modification alternative.
