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Published on: June 20, 2016
YidC/Alb3/Oxa1 Family of Insertases
Seth W Hennon1, Raunak Soman1, Lu Zhu1
1From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210.
Abstract:
The YidC/Alb3/Oxa1 family functions in the insertion and folding of proteins in the bacterial cytoplasmic membrane, the chloroplast thylakoid membrane, and the mitochondrial inner membrane. All members share a conserved region composed of five transmembrane regions. These proteins mediate membrane insertion of an assorted group of proteins, ranging from respiratory subunits in the mitochondria and light-harvesting chlorophyll-binding proteins in chloroplasts to ATP synthase subunits in bacteria. This review discusses the YidC/Alb3/Oxa1 protein family as well as their function in membrane insertion and two new structures of the bacterial YidC, which suggest a mechanism for membrane insertion by this family of insertases.
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