Related Experiment Video
Updated: Apr 12, 2026
Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
Role of MicroRNAs in Malignant Glioma
1Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai JiaoTong University, Shanghai 200092, China.
Objective:
This overview seeked to bring together the microRNA (miRNA) researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma.
Data Sources:
Using the keyword terms "glioma" and "miRNA," we performed the literature search in PubMed, Ovid, and web.metstr.com databases from their inception to October 2014.
Study Selection:
In screening out the quality of the articles, factors such as clinical setting of the study, the size of clinical samples were taken into consideration. Animal studied for verification and reviews article were also included in our data collection.
Results:
Despite many advance in miRNA for malignant glioma, further studies were still required to focus on the following aspects: (i) Improving the understanding about biogenesis of miRNA and up-down regulation; (ii) utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma; (iii) Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of glioma.
Conclusions:
We discussed the most promising miRNA, correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy.
Insights
MicroRNAs (miRNAs) show promise in malignant glioma diagnosis and therapy. Further research is needed to understand miRNA biogenesis, identify key miRNAs, and explore their role in glioma growth signaling pathways.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Malignant glioma is a significant challenge in neuro-oncology.
- MicroRNAs (miRNAs) are emerging as critical regulators in cancer development and progression.
Purpose of the Study:
- To synthesize current research on microRNA (miRNA) biogenesis and function in malignant glioma.
- To evaluate the potential of miRNAs in clinical diagnosis and therapy for glioma.
Main Methods:
- Comprehensive literature search of PubMed, Ovid, and web.metstr.com databases up to October 2014.
- Inclusion criteria focused on clinical studies, sample size, animal verification studies, and review articles.
Main Results:
- Significant advancements in miRNA research for malignant glioma exist.
- Further studies are required to elucidate miRNA biogenesis and regulation.
- High-throughput analysis is needed to identify core glioma-associated miRNAs.
- Investigating miRNA involvement in glioma proliferation and growth signaling pathways is crucial.
Conclusions:
- Promising miRNAs and associated signaling pathways offer potential for novel glioma therapeutic strategies.
- Translating miRNA research into clinical applications requires further investigation.
Related Concept Videos
01:22MicroRNAs
01:22MicroRNAs
01:22MicroRNAs