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[The synthesis of P-substituted DL-2-phenylglycine octylesters]
W D Sprung1, M Kobow, E Schulz
1Institut für Pharmakologie und Toxikologie Bereich Medizin der Wilhelm-Pieck-Universität Rostock.
Die Pharmazie
|August 1, 1989
Abstract:
9 Titel compounds (p-RC6H4)CH(NH2.HCl)COO (CH2)7CH3 [R = F, Cl, HO, CH3O, CH3(CH2)3O, C6H5CH2O, CH3, (CH3)2CH and (CH3)2N.HCl] were obtained by esterification of p-substituted DL-2-phenylglycines with octanol either in the presence of dry hydrogen chloride (procedure A) or with thionyl chloride (procedure B). The advantages of the procedure B are the mild conditions, the more pure products, the possibility of esterification of diamino acids, and the stability of alkoxy groups as substituents. The synthesized octylesters are potential antiinflammatory and analgesic substances with spasmolytic activity.