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Menarche increases relapse risk in pediatric multiple sclerosis.

Sabeen Lulu1, Jennifer Graves2, Emmanuelle Waubant2

  • 1University of California, USA sabeen.lulu@gmail.com.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 8, 2015
PubMed
Summary
This summary is machine-generated.

Puberty significantly impacts multiple sclerosis (MS) disease course in girls. The peri-menarche period shows a marked increase in MS relapses compared to post-menarche, highlighting puberty

Keywords:
Multiple sclerosisoutcome measurementrelapsing–remitting

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Area of Science:

  • Neurology
  • Pediatrics
  • Immunology

Background:

  • Multiple sclerosis (MS) predominantly affects women, with a 3:1 sex ratio, contrasting the 1:1 ratio in pre-pubertal onset.
  • Puberty's differential influence on MS risk and disease course in males versus females remains largely unknown.

Purpose of the Study:

  • To investigate the association between menarche timing and the disease course in girls diagnosed with MS.

Main Methods:

  • A longitudinal retrospective study analyzed data from the UCSF Regional Pediatric MS Center.
  • Patients were categorized based on disease onset relative to menarche: pre-menarche, peri-menarche, and post-menarche.
  • Within-subject relapse analyses were performed using Poisson regression models, adjusted for follow-up time.

Main Results:

  • The study included 76 girls, with onset groups of pre-menarche (n=17), peri-menarche (n=9), and post-menarche (n=50).
  • While the age of menarche was similar across groups, relapse rates were comparable in the first two years post-onset.
  • However, within-subject analyses revealed a significant increase in relapses during the peri-menarche period compared to the post-menarche period (adjusted IRR = 8.5, p = 0.001).

Conclusions:

  • Pubertal status appears to be a significant factor influencing the disease course in female MS patients.
  • Further understanding of puberty's role in MS clinical features may provide crucial insights into disease regulation mechanisms.