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Related Experiment Video

Updated: Apr 12, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing.

Zahi I Mitri¹, Michelle Jackson¹, Carolyn Garby¹

¹University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Baylor Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA; University of Texas Health and Science Center at Houston, Houston, Texas, USA.

|May 8, 2015

Summary

The BRCAPRO model effectively assesses the risk of BRCA mutations in men, aiding in identifying those who need genetic testing for hereditary cancer syndromes.

Keywords:

BRCA BRCAPRO Cancer genetics Genetic counseling Male breast cancer Risk models

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Last Updated: Apr 12, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

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Published on: February 28, 2021

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

Area of Science:

Genetics
Oncology
Risk Assessment

Background:

BRCAPRO is a validated risk model for BRCA mutations in women.
BRCA mutations increase cancer risk (breast, ovarian, pancreatic, prostate).
Previous models lacked validation for male populations.

Purpose of the Study:

To evaluate the BRCAPRO model's accuracy in predicting BRCA mutations in men.
To assess BRCAPRO's utility in male genetic counseling settings.

Main Methods:

146 men undergoing genetic counseling and testing were analyzed.
BRCAPRO scores were calculated using CancerGene software.
BRCA mutation status was determined via genetic testing.

Main Results:

34% of men tested positive for BRCA mutations (BRCA1/BRCA2).
BRCAPRO scores were significantly higher in mutation carriers (46.19% vs. 13.9%).
The model demonstrated good predictive performance (AUC 0.83, sensitivity 0.74, specificity 0.81).

Conclusions:

BRCAPRO is a valid tool for assessing BRCA mutation risk in men.
The model can help identify high-risk men for genetic testing.
Findings support BRCAPRO's use in male cancer risk assessment.