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Behavioral performance and seizure activity of lithium-intoxicated Sprague-Dawley rats treated with theophylline
K H Andersen1, P J Perry, A D Sherman
1Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.
Psychiatry Research
|October 1, 1989
Abstract:
Male Sprague-Dawley rats were divided into four groups that were treated with various combinations of lithium, saline, and theophylline, i.e., saline/saline, saline/theophylline, lithium/theophylline, and lithium/saline. Neurobehavioral testing of cerebellar and neuromuscular functioning, and determination of the effect of the drug combinations on the animals' seizure threshold concluded that while theophylline increases lithium clearance, it does not exacerbate lithium neurotoxicity.