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Updated: Apr 12, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
MAVS Coordination of Antiviral Innate Immunity
Christine Vazquez1, Stacy M Horner2
1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Abstract:
RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to trigger the antiviral innate immune response. Here, we describe how MAVS subcellular localization impacts its function and the regulation underlying MAVS signaling. We propose a model to describe how the coordination of MAVS functions at the interface between the mitochondria and the mitochondrion-associated endoplasmic reticulum (ER) membrane programs antiviral signaling.
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