Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

3.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.4K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

238
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
238
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

8.4K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
8.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

10.2K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.2K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

10.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.7K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

87.6K
Overview
87.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Deep Learning-Based Pattern Recognition for Detecting Penile Abnormalities: Protocol for Developing a Mobile App for Circumcision Eligibility.

JMIR research protocols·2026
Same author

Reflective versus predictive value of urinary podocin, nephrin, and their ratio in diabetic kidney disease: a 12-month retrospective cohort study.

Frontiers in nephrology·2026
Same author

Modulation of renal inflammation and tubular injury by calcitriol in patients with early diabetic kidney disease: a randomized controlled trial.

Annals of medicine·2025
Same author

Correlation of Serum FT4 with Serum Uric Acid and Comparison of Uric Acid in Subjects with and without Atrial Fibrillation in Graves' Disease: A Cross-Sectional Study.

Acta medica Indonesiana·2025
Same author

Atherogenic Lipoprotein Profile in First-Degree Relatives of Individuals with Type 2 Diabetes Mellitus.

Acta medica Indonesiana·2025
Same author

Association Between Leptin and Adiponectin Levels and Sarcopenia in Non-Geriatric Type 2 Diabetes Mellitus Patients.

Acta medica Indonesiana·2025

Related Experiment Video

Updated: Apr 12, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

11.3K

Dendritic cells in Graves' disease.

Dyah Purnamasari1, Pradana Soewondo, Samsuridjal Djauzi

  • 1Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Acta Medica Indonesiana
|May 8, 2015
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) play a key role in Graves

More Related Videos

Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus
09:07

Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus

Published on: September 19, 2013

20.1K
Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

869

Related Experiment Videos

Last Updated: Apr 12, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

11.3K
Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus
09:07

Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus

Published on: September 19, 2013

20.1K
Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

869

Area of Science:

  • Immunology
  • Endocrinology
  • Autoimmunity

Background:

  • Dendritic cells (DCs) are crucial antigen-presenting cells (APCs) initiating adaptive immunity by activating T cells.
  • Graves' disease (GD) is an autoimmune disorder involving autoantibodies against the Thyroid Stimulating Hormone Receptor (TSHR), leading to hyperthyroidism.
  • While thyrocytes in GD can express MHC class II, DCs remain the primary APCs in the disease's immune response.

Purpose of the Study:

  • To investigate the role and characteristics of dendritic cells (DCs) in the immune response of Graves' disease (GD).
  • To explore the controversial findings regarding DC numbers and profiles in GD patients.
  • To understand the potential link between DC alterations and regulatory T cell (Treg) defects in GD.

Main Methods:

  • Isolation and analysis of intra-thyroid dendritic cells (DCs) from Graves' disease patients.
  • Analysis of dendritic cells (DCs) in the peripheral circulation of Graves' disease patients.
  • Characterization of DC numbers, profiles, and potential association with regulatory T cell (Treg) function.

Main Results:

  • Studies on dendritic cells (DCs) in Graves' disease (GD) have yielded controversial results.
  • Alterations in the number and profile of dendritic cells (DCs) have been observed in GD.
  • These DC changes suggest modified immune response activity and potential defects in regulatory T cells (Tregs) in GD.

Conclusions:

  • Dendritic cells (DCs) are implicated in the immune dysregulation characteristic of Graves' disease (GD).
  • Observed changes in DC populations highlight their altered function in the autoimmune thyroid environment.
  • Further research is warranted to clarify the precise role of DCs and their connection to Treg dysfunction in GD pathogenesis.