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Matrix metalloproteinases in inflammatory bowel disease: an update
Shane O'Sullivan1, John F Gilmer1, Carlos Medina1
1School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland.
Mediators of Inflammation
|May 8, 2015
Summary
Matrix metalloproteinases (MMPs) are upregulated in inflammatory bowel disease (IBD). This review explores their diverse roles in IBD pathophysiology and potential as therapeutic targets.
Area of Science:
- Gastroenterology and Immunology
Background:
- Matrix metalloproteinases (MMPs) are implicated in inflammatory bowel disease (IBD) and other inflammatory conditions.
- Their precise roles in IBD pathogenesis are still being elucidated, despite clear upregulation.
Purpose of the Study:
- To review recent findings on the diverse roles of MMPs in IBD.
- To highlight MMPs as potential biomarkers and therapeutic targets for IBD.
Main Methods:
- Literature review of studies on MMPs in IBD since 2006.
- Analysis of MMP involvement in immune and stromal cell responses to inflammatory stimuli.
Main Results:
- MMPs are released by various cells in response to cytokines and growth factors.
- MMPs regulate key processes in IBD including barrier function, immune response, angiogenesis, fibrosis, and wound healing.
Conclusions:
- MMPs play multifaceted roles in IBD pathophysiology.
- Further research into MMPs may lead to novel diagnostic and therapeutic strategies for IBD.
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