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Gorham's disease: A diagnostic challenge.

Fatema Y Saify1, Suchitra R Gosavi2

  • 1Department of Oral Pathology, Government Dental College, Raipur, Chhattisgarh, India.

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|May 8, 2015
PubMed
Summary
This summary is machine-generated.

Gorham's disease, also known as vanishing bone disease, causes progressive bone loss. This review aims to increase awareness of this rare condition and its management.

Keywords:
Gorham's diseasemandiblemassive osteolysisvanishing bone disease

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Area of Science:

  • Osteology
  • Rare diseases
  • Medical review

Background:

  • Gorham's disease is a rare idiopathic disorder characterized by progressive osteolysis.
  • Fewer than 200 cases reported globally, with 51 in the maxillofacial region.
  • Radiographic findings can be dramatic, showing complete bone resorption, earning it the name 'phantom bone' or 'disappearing bone disease'.

Purpose of the Study:

  • To raise awareness of Gorham's disease within the medical community.
  • To provide a comprehensive overview of vanishing bone disease.
  • To discuss current understanding and management strategies.

Main Methods:

  • Literature review of Gorham's disease.
  • Synthesis of information on etiopathology, clinical presentation, and radiographic findings.
  • Compilation of histopathology, differential diagnoses, and treatment options.

Main Results:

  • Gorham's disease presents with progressive osteolysis of affected bones.
  • Maxillofacial involvement is noted in a significant subset of reported cases.
  • Radiographic evidence includes potential for complete bone resorption.

Conclusions:

  • Gorham's disease requires increased clinical awareness due to its rarity and potential for severe bone loss.
  • Understanding the etiopathology, presentation, and diagnosis is crucial for effective management.
  • Further research may elucidate specific treatment modalities for this vanishing bone disorder.