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Related Concept Videos

Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Related Experiment Video

Updated: Apr 12, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Fus expression patterns in developing tooth.

Eun-Jung Kim1, Jong-Min Lee1, Han-Sung Jung2

  • 1Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 120-752, Republic of Korea.

Development & Reproduction
|May 8, 2015
PubMed
Summary
This summary is machine-generated.

The RNA/DNA-binding protein FUS plays a role in tooth development. This study found FUS is expressed in key structures like the dental papilla and Hertwig's epithelial root sheath (HERS), suggesting its involvement in root formation.

Keywords:
FusHertwig’s epithelial root sheathIn situ hybridization.Tooth

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The RNA/DNA-binding protein FUS (Fused in sarcoma) is implicated in vertebrate growth, differentiation, and morphogenesis.
  • Limited information exists regarding the specific functions of FUS during mammalian tooth development.

Purpose of the Study:

  • To investigate the expression pattern of FUS during murine tooth development.
  • To elucidate the potential role of FUS in tooth morphogenesis and root development.

Main Methods:

  • In situ hybridization was employed to detect FUS mRNA expression in developing mouse mandibles.
  • Analysis was conducted across various embryonic (days postcoitum) and postnatal developmental stages.

Main Results:

  • FUS expression was observed in the dental epithelium and mesenchyme early in development (11-12 dpc).
  • Strong FUS expression was noted in the dental papilla and cervical loop from 14 dpc onwards.
  • Postnatally, FUS was detected in odontoblasts, ameloblasts, pulp proliferation zones, and notably, Hertwig's epithelial root sheath (HERS) at PN14.

Conclusions:

  • The expression pattern of FUS suggests its involvement in various stages of murine tooth development.
  • FUS expression, particularly in the HERS, indicates a potential role in regulating root development.