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Related Experiment Videos

Cocaine enhances memory storage in mice.

I B Introini-Collison1, J L McGaugh

  • 1Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.

Psychopharmacology
|January 1, 1989
PubMed
Summary

Cocaine administered immediately after training enhances memory retention in mice. This effect is time-dependent, suggesting cocaine influences memory storage processes.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Inhibitory avoidance tasks are used to study learning and memory.
  • Cocaine is a stimulant drug with known effects on the central nervous system.

Purpose of the Study:

  • To investigate the effect of post-training cocaine administration on memory retention.
  • To determine the time-dependency and specificity of cocaine's influence on memory storage.

Main Methods:

  • Mice were trained on a one-trial inhibitory avoidance task.
  • Cocaine (0.03-1.00 mg/kg) was administered intraperitoneally immediately after training.
  • Memory retention was assessed 24 hours later by measuring retention latencies.
  • Time-dependency was tested by administering cocaine 60 minutes post-training.
  • The effect of pre-test cocaine administration was also evaluated.

Main Results:

  • A cocaine dose of 0.10 mg/kg significantly increased retention latencies compared to controls.
  • The memory-enhancing effect of cocaine was time-dependent, as administration 60 minutes post-training had no effect.
  • Administering cocaine before the retention test did not alter performance in mice that received saline or cocaine post-training.

Conclusions:

  • Cocaine administration immediately after inhibitory avoidance training enhances memory retention in mice.
  • The findings indicate that cocaine influences post-training memory consolidation processes.
  • The time-sensitive nature of this effect suggests a critical window for cocaine's impact on memory storage.

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