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Haemochromatosis in end-stage renal disease: when waste is a treatment option
Tobias Oettl1, Michael Dickenmann1
1Transplantation Immunology and Nephrology , University Hospital , Basel , Switzerland.
For patients with end-stage renal disease and hereditary haemochromatosis, prevention and treatment of anaemia differ from usual nephrologic guidelines. Monitoring of individual disease progression and ferritin levels is crucial. We describe a case of a young haemodialysis patient with early-stage organ dysfunction caused by hereditary haemochromatosis, in whom iron stores have successfully been depleted with phlebotomy and supplemental erythropoietin over 22 months. Target ferritin levels could finally be reached without severe, persisting or symptomatic anaemia.
For patients with end-stage renal disease and hereditary haemochromatosis, prevention and treatment of anaemia differ from usual nephrologic guidelines. Monitoring of individual disease progression and ferritin levels is crucial. We describe a case of a young haemodialysis patient with early-stage organ dysfunction caused by hereditary haemochromatosis, in whom iron stores have successfully been depleted with phlebotomy and supplemental erythropoietin over 22 months. Target ferritin levels could finally be reached without severe, persisting or symptomatic anaemia.
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Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

