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MPO-ANCA crescentic glomerulonephritis complicated by membranous nephropathy: MPO demonstrated in epimembranous

Kei Matsumoto1, Hirokazu Honda1, Takanori Shibata1

  • 1Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.

NDT Plus
|May 8, 2015
PubMed

Insights

This study shows myeloperoxidase (MPO) and MPO-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA) may cause IgG deposits in kidney glomeruli. These deposits were observed in an elderly woman with hematuria and proteinuria.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA) are associated with glomerulonephritis.
  • The role of MPO and MPO-ANCA in glomerular immune deposition is not fully understood.
Keywords:
MPO-ANCAmembranous glomerulopathymyeloperoxidase

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