Antibiotic prescribing for upper respiratory tract infections in children: how can we improve?

Graham Easton1, Sonia Saxena2

  • 1General Practitioner, Ealing PCT, London, UK and Senior Clinical Teaching Fellow, Department of Primary Care and Public Health, Imperial College London, UK.

Insights

Antibiotic prescribing for pediatric upper respiratory tract infections (URTIs) is increasing despite limited benefits. This article examines reasons for this trend and offers practical solutions for general practitioners (GPs) to implement guideline recommendations.

Area of Science:

  • Pediatrics
  • General Practice
  • Infectious Diseases

Background:

  • Upper respiratory tract infections (URTIs) are highly prevalent in pediatric populations.
  • Antibiotic use for uncomplicated URTIs in children is often inappropriate, as complications are rare and antibiotics provide minimal benefit.
  • Recent trends show an increase in antibiotic prescribing for pediatric URTIs, reversing a previous decline.

Purpose of the Study:

  • To explore the reasons behind the recent increase in antibiotic prescribing for pediatric URTIs.
  • To evaluate the evidence for withholding antibiotics in uncomplicated URTIs.
  • To guide general practitioners (GPs) in interpreting and applying National Institute for Health and Clinical Excellence (NICE) guidelines for pediatric URTI management.

Main Methods:

  • Review of current literature on URTI treatment and antibiotic stewardship in children.
  • Analysis of prescribing trends and influencing factors.
  • Exploration of strategies for guideline implementation in primary care settings.

Main Results:

  • Identified factors contributing to increased antibiotic prescribing, including diagnostic uncertainty and patient expectations.
  • Highlighted the limited efficacy of antibiotics in uncomplicated pediatric URTIs.
  • Discussed challenges faced by GPs in adhering to antibiotic prescribing guidelines.

Conclusions:

  • Emphasized the need for improved understanding and implementation of evidence-based guidelines for pediatric URTI management.
  • Suggested practical approaches to support GPs in reducing unnecessary antibiotic prescriptions.
  • Advocated for strategies to align clinical practice with NICE recommendations for URTI in children.

Related Concept Videos

Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
1.0K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
389
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
1.7K
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
612
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
40
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
868