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Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy

Oana Draghiciu1, Joyce Lubbers1, Hans W Nijman2

  • 1Department of Medical Microbiology; Tumor Virology and Cancer Immunotherapy; University of Groningen; University Medical Center Groningen ; Groningen, The Netherlands.

Oncoimmunology
|May 8, 2015
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) promote cancer immune evasion. Targeting MDSCs through various strategies, including differentiation, blockade, inhibition, or depletion, offers promising avenues for improving cancer treatment outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Therapy

Background:

  • Myeloid-derived suppressor cells (MDSCs) are key players in tumor-induced immune suppression.
  • Elevated MDSC levels correlate with poor prognosis in cancer patients.
  • MDSCs facilitate tumor immune escape, hindering effective anti-cancer responses.

Conclusions:

  • Targeting MDSCs represents a viable strategy to overcome tumor immune escape.
  • Interventions aimed at different stages of MDSC biology can be employed for cancer therapy.
  • Combined therapeutic approaches targeting MDSCs may enhance overall treatment efficacy in cancer patients.
Keywords:
5-FU, 5-fluorouracil5-FluorouracilADAM17, metalloproteinase domain-containing protein 17APCs, antigen presenting cellsARG1, arginase-1ATRA, all-trans retinoic acidCCL2, chemokine (C-C motif) ligand 2CD62L, L-selectinCDDO-Me, bardoxolone methylCOX2, cyclooxygenase 2CTLs, cytotoxic T lymphocytesCXCL12, chemokine (C-X-C motif) ligand 12CXCL15, chemokine (C-X-C motif) ligand 15DCs, dendritic cellsERK1/2, extracellular signal-regulated kinasesFlt3, Fms-like tyrosine kinase 3FoxP3, forkhead box P3GITR, anti-glucocorticoid tumor necrosis factor receptorGM-CSF/CSF2, granulocyte monocyte colony stimulating factorGSH, glutathioneHIF-1α, hypoxia inducible factor 1αHLA, human leukocyte antigenHNSCC, head and neck squamous cell carcinomaHPV-16, human papillomavirus 16HSCs, hematopoietic stem cellsICT, 3, 5, 7-trihydroxy-4′-emthoxy-8-(3-hydroxy-3-methylbutyl)-flavoneIFNγ, interferon γIL-10, interleukin 10IL-13, interleukin 13IL-1β, interleukin 1 βIL-4, interleukin 4IL-6, interleukin 6IMCs, immature myeloid cellsJAK2, Janus kinase 2MDSCs, myeloid-derived suppressor cellsMMPs, metalloproteinases (e.g., MMP9)Myd88, myeloid differentiation primary response protein 88NAC, N-acetyl cysteineNADPH, nicotinamide adenine dinucleotide phosphate-oxidase NK cells, natural killer cellsNO, nitric oxideNOHA, N-hydroxy-L-ArginineNSAID, nonsteroidal anti-inflammatory drugsODN, oligodeoxynucleotidesPDE-5, phosphodiesterase type 5PGE2, prostaglandin E2RNS, reactive nitrogen speciesROS, reactive oxygen speciesSCF, stem cell factorSTAT3, signal transducer and activator of transcription 3TAMs, tumor-associated macrophagesTCR, T cell receptorTGFβ, transforming growth factor βTNFα, tumor necrosis factor αTregs, regulatory T cellsVEGFR, vascular endothelial growth factor receptorWA, withaferin AWRE, Withaferin somniferaall-trans retinoic acidbisphosphonatesc-kit, Mast/stem cell growth factor receptorgemcitabineiNOS2, inducible nitric oxid synthase 2immune suppressive mechanismsmRCC, metastatic renal cell carcinomamyeloid-derived suppressor cellssunitinib therapeutic vaccination

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