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Updated: Apr 12, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
BRAF-inhibition and tumor immune suppression
Shannon M Steinberg1, Mary Jo Turk2
1Department of Microbiology and Immunology; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center ; Lebanon, NH USA.
Abstract:
As BRAFV600E-inhibitors become standard treatment for many metastatic melanoma patients, research has begun to elucidate their impact on the tumor immune landscape. Here, we highlight our recent studies demonstrating the ability of melanoma cell-intrinsic BRAFV600E-inhibition to selectively reduce intratumoral immunosuppressive cell populations and enhance antitumor CD8+ T-cell immunity.
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