Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

329
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
329
Renal Corpuscle01:20

Renal Corpuscle

9.5K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
9.5K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

816
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
816
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

365
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
365
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.0K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.0K
Nephrons01:10

Nephrons

9.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
9.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolomic profiling in IgA nephropathy: urinary and salivary biomarker insights.

BMC nephrology·2026
Same author

Serum calcitonin gene-related peptide and neuropeptide Y levels in seborrheic dermatitis: comparison with healthy controls and correlation with disease severity.

Cutaneous and ocular toxicology·2026
Same author

Clinicopathologic features and outcomes of patients with DNAJB9-positive fibrillary glomerulonephritis.

Clinical kidney journal·2026
Same author

Sex Differences in Baseline Characteristics and Long-Term Outcomes of Primary Glomerular Diseases: Insights from the TSN-GOLD Registry.

Journal of clinical medicine·2026
Same author

Burden and correlates of anemia in IgA nephropathy versus other primary glomerulonephritides.

BMC nephrology·2026
Same author

Interstitial Fibrosis Severity Is Not Independently Associated with Anemia in Biopsy-Proven Primary Glomerulonephritis: A Nationwide Registry Analysis.

Medicina (Kaunas, Lithuania)·2026

Related Experiment Video

Updated: Apr 12, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.8K

Primary glomerular diseases in the elderly.

Abdullah Sumnu1, Meltem Gursu1, Savas Ozturk1

  • 1Abdullah Sumnu, Okmeydani Training and Research Hospital, 34390 Istanbul, Turkey.

World Journal of Nephrology
|May 8, 2015
PubMed
Summary

Primary glomerular diseases present unique challenges in the elderly. Renal biopsy is crucial for accurate diagnosis and treatment decisions in older adults with kidney conditions.

Keywords:
ElderlyMembranous nephropathyPauci-immune crescentic glomerulonephritisPrimary glomerular diseaseRenal biopsy

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.9K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K

Related Experiment Videos

Last Updated: Apr 12, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.8K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.9K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K

Area of Science:

  • Nephrology
  • Geriatric Medicine
  • Internal Medicine

Background:

  • Primary glomerular diseases (PGDs) pose diagnostic and therapeutic challenges in the elderly.
  • Membranous nephropathy is the most common PGD in older adults, unlike IgA nephropathy in younger populations.
  • Membranous nephropathy is also the leading cause of nephrotic syndrome in the elderly.

Purpose of the Study:

  • To highlight the distinct characteristics and management considerations of PGDs in the elderly.
  • To emphasize the importance of renal biopsy in diagnosing and managing PGDs in older individuals.
  • To discuss factors influencing treatment decisions for PGDs in elderly patients.

Main Methods:

  • Review of current literature and clinical observations regarding PGDs in the elderly.
  • Analysis of diagnostic challenges and treatment strategies specific to this demographic.
  • Emphasis on the role of renal biopsy and individualized treatment planning.

Main Results:

  • Membranous nephropathy and pauci-immune crescentic glomerulonephritis (GN) are significant PGDs in the elderly.
  • Pauci-immune crescentic GNs are medical emergencies in the elderly due to risks of end-stage renal disease and mortality.
  • Elderly patients often present with worse renal function, higher rates of acute kidney injury, and hypertension.

Conclusions:

  • Renal biopsy is essential for accurate diagnosis and prognosis in elderly patients with PGDs, regardless of age.
  • Treatment decisions for PGDs in the elderly require careful consideration of comorbidities, drug interactions, and patient-specific factors.
  • Advanced age should not preclude renal biopsy or appropriate management of PGDs.