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Updated: Apr 12, 2026
In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane
Published on: November 28, 2019
The absence of human papillomavirus in amniotic fluid
G L Maxwell1, J Carlson, M Zakarean
1*Departments of Obstetrics-Gynecology ‡Department of Clinical investigation, William Beaumont Anny Medical Center, El Paso, TX †Department of Obstetrics-Gynecology, Texas Tech Health Sciences Center, El Paso, TX.
Objectives:
The objective of this multicenter trial was to determine the incidence of human papillomavirus (HPV) in the amniotic fluid of pregnant patients.
Methods:
Fifty-three pregnant patients undergoing genetic counseling or amniocentesis for preterm labor were entered into the study. Cervical swabs and amniotic fluid samples were ob-tained at the time of entry. Demographical questionnaires were completed by all patients. All samples underwent HPV analysis using polymerase chain reaction.
Results:
The incidence of cervical HPV and cervical intraepithelial neoplasia in this population was 24% and 4%, respectively. The analysis of 49 amniotic fluid samples revealed the absence of HPV in each specimen.
Conclusions:
The absence of HPV in the amniotic fluid of patients with cervical colonization does not support a mechanism of prenatal transmission in the general population.
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