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Persistence of Ebola Virus in Ocular Fluid during Convalescence
Jay B Varkey1, Jessica G Shantha, Ian Crozier
1From the Department of Medicine, Division of Infectious Diseases (J.B.V., C.S.K., G.M.L., A.K.M., B.S.R.), the Department of Ophthalmology (J.G.S., G.K., S.Y.), and the Department of Pathology and Laboratory Medicine (C.S.K.), Emory University School of Medicine, and the Centers for Disease Control and Prevention (M.H.K., S.W., U.S., T.M.U.) - both in Atlanta; the Infectious Diseases Institute, Mulago Hospital Complex, Kampala, Uganda (I.C.); and Flinders University, Adelaide, SA, Australia (J.R.S.).
Abstract:
Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.
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