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Updated: Apr 12, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
Published on: January 17, 2012
NODding off in acute kidney injury with progranulin?
Raghu K Tadagavadi1, W Brian Reeves1
1Division of Nephrology, Department of Medicine, Penn State Hershey Medical Center and College of Medicine, Hershey, Pennsylvania, USA.
Abstract:
Zhou et al. identify progranulin (PGRN) as a protective mediator that limits inflammation in murine models of acute kidney injury (AKI) and reduces its severity. Deficiency of PGRN was associated with increased inflammation and increased injury in ischemic and nephrotoxic models of AKI. Exogenous PGRN reduced AKI even when administered after AKI was established. Interference in NOD2 pathways is suggested as a possible mechanism for protection. PGRN-based therapeutics might have application in the treatment or prevention of AKI.
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