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Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

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Severe bronchiectasis in a patient with common variable immunodeficiency.

L Paulos Viegas¹, S P Silva², S L Silva³

¹Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte CHLN, Lisboa, Portugal. Av. Professor Egas Moniz 1649-035 Lisbon, Portugal. E-mail: viegas.lp@gmail.com Phone: +351 918 65 11 06.

European Annals of Allergy and Clinical Immunology

|May 8, 2015

Summary

Common Variable Immunodeficiency (CVID) patients with bronchiectasis require regular screening for Pseudomonas aeruginosa. Early and aggressive eradication therapy improves lung function and clinical outcomes in these patients.

Keywords:

CVID Pseudomonas bronchiectasis

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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

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Published on: March 17, 2014

Area of Science:

Pulmonology
Immunology
Infectious Diseases

Background:

Bronchiectasis is a frequent complication in patients with Common Variable Immunodeficiency (CVID).
CVID patients are susceptible to recurrent infections, leading to lung damage and reduced FEV1.
Progressive lung destruction is a hallmark of CVID-associated bronchiectasis.

Observation:

A 40-year-old male with a history of recurrent respiratory infections, autoimmunity, and diarrhea since age 7.
CVID diagnosed at 17, treated with IVIgG; symptoms worsened over time.
Thoracic CT revealed bronchiectasis; Pseudomonas aeruginosa identified in bronchoalveolar lavage and bronchial secretions.

Findings:

Pseudomonas aeruginosa infection in CVID-associated bronchiectasis.
Successful eradication therapy led to clinical improvement.
Aggressive treatment strategies are crucial for managing CVID complications.

Implications:

Highlights the importance of routine microbiological surveillance in CVID patients with bronchiectasis.
Emphasizes the need for prompt and effective antibiotic therapy to prevent disease progression.
Early and aggressive intervention can significantly alter the clinical trajectory of CVID patients.