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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

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Targeted Therapies for Prostate Cancer

Roberto Petrioli1, Edoardo Francini, Anna Ida Fiaschi

  • 1Medical Oncology Unit, University of Siena , Siena , Italy 1.

Cancer Investigation
|May 8, 2015
PubMed

Insights

New prostate cancer therapies show limited efficacy and resistance is common. Innovative treatments are needed, as combining existing therapies has not improved survival in recent trials.

Area of Science:

  • Oncology
  • Urology
  • Pharmacology

Background:

  • Recent advancements in prostate cancer therapeutics have been made.
  • Current treatments often lead to acquired resistance.
  • Curative options remain limited for advanced prostate cancer.

Purpose of the Study:

  • To review the current landscape of novel prostate cancer therapies.
  • To address the unmet need for treatments overcoming therapeutic resistance.
  • To evaluate the efficacy of combination therapies in prostate cancer.

Main Methods:

  • Review of recent clinical trials and therapeutic strategies.
  • Analysis of data from phase III trials involving docetaxel and targeted therapies.
  • Assessment of emerging combination treatment approaches.

Main Results:

  • New prostate cancer therapies have emerged but are not curative.
  • Combination of docetaxel with targeted therapies showed no survival benefit in a phase III trial.
  • Limited data exists on combining targeted therapies with novel agents.

Conclusions:

  • Development of innovative therapies to overcome resistance is crucial.
  • Further clinical investigation into novel combination treatments is warranted.
  • Ongoing clinical trials are essential to determine the efficacy of new therapeutic strategies.
Keywords:
Biologic agentsDocetaxelProstate cancerTarget therapy

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