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Related Concept Videos

Tight Junctions01:29

Tight Junctions

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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Transcellular Transport of Solutes01:23

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Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
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Cystic Fibrosis: Pathogenesis01:23

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Breathing01:05

Breathing

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The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Related Experiment Video

Updated: Apr 12, 2026

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
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Claudins: Gatekeepers of lung epithelial function.

Barbara Schlingmann1, Samuel A Molina1, Michael Koval1

  • 1Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, United States.

Seminars in Cell & Developmental Biology
|May 9, 2015
PubMed
Summary

Lung epithelial cells use claudins to maintain barrier function and fluid balance. Claudin-18 and claudin-4 also regulate lung cell phenotype and inflammation, suggesting broader physiological roles.

Keywords:
AirwayAlveolarizationAlveolusCystic fibrosisPulmonary edemaVascular endothelium

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Area of Science:

  • Pulmonary physiology
  • Cell biology
  • Molecular biology

Background:

  • Lung epithelial cells form a critical barrier for fluid balance.
  • Tight junction proteins, particularly claudins, are essential for epithelial barrier integrity.
  • Different respiratory segments have varying fluid requirements and distinct claudin compositions.

Purpose of the Study:

  • To investigate the roles of specific claudins in maintaining lung barrier function.
  • To explore the functions of claudins beyond paracellular permeability.
  • To understand claudin involvement in lung physiology and disease.

Main Methods:

  • In vitro cell culture models
  • In vivo animal studies
  • Histologic analysis of human lung tissue

Main Results:

  • Claudin-18 is uniquely expressed in alveolar epithelial cells.
  • Claudin-4 and claudin-7 are widely expressed in the respiratory epithelium.
  • Claudin-5 is found in both pulmonary epithelial and endothelial cells.
  • Claudin-18 and claudin-4 influence lung cell phenotype and inflammation.

Conclusions:

  • Claudins play multifaceted roles in lung physiology, extending beyond barrier function.
  • Specific claudins like claudin-18 and claudin-4 have significant impacts on lung cell behavior and inflammatory responses.
  • Further research into claudin functions is crucial for understanding and treating lung diseases.