Related Experiment Video
Updated: Apr 12, 2026
09:58
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
23.6K
Measuring the corticosteroid responsiveness endophenotype in asthmatic patients
George L Clemmer1, Ann Chen Wu2, Bernard Rosner1
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
The Journal of Allergy and Clinical Immunology
|May 9, 2015
Summary
A new composite phenotype accurately measures corticosteroid responsiveness in asthma, outperforming individual clinical measures. This approach enhances the modeling of corticosteroid pharmacologic response and resistance.
Area of Science:
- Pulmonary Medicine
- Pharmacogenomics
- Biostatistics
Background:
- Inhaled corticosteroids are standard asthma controller therapy.
- Treatment response is observed across six clinical phenotypes.
- A single quantitative endophenotype is hypothesized to modulate these responses.
Purpose of the Study:
- Develop a composite phenotype for corticosteroid responsiveness.
- Ensure accuracy, population stability, and robustness to missing data.
- Improve modeling of corticosteroid pharmacologic response and resistance.
Main Methods:
- Principal component analysis used to derive a composite phenotype.
- Tested in four independent replication populations.
- Area Under the Receiver Operating Characteristic Curve (AUC) evaluated accuracy.
Main Results:
- Composite phenotype achieved an AUC of 0.74 in the primary study.
- This significantly surpassed individual clinical phenotypes (AUCs 0.56–0.67).
- In replication populations, composite AUCs (0.69–0.73) outperformed 14/22 phenotypes.
Conclusions:
- The composite phenotype offers superior accuracy, stability, and robustness.
- It provides enhanced capability for modeling corticosteroid response and resistance.
- This advances personalized medicine approaches in asthma management.
More Related Videos
Related Concept Videos
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
2.0K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
2.0K
01:26Asthma-II: Pathophysiology and Classification
5.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
5.0K
01:20Asthma: Pathogenesis and Management
1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
01:30Asthma-IV: Diagnostic and Management
3.3K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.2K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.2K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.4K