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Updated: Apr 12, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Chronic whiplash pain
Richard Seroussi1, Virtaj Singh1, Adrielle Fry2
1Department of Rehabilitation Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356490, Seattle, WA 98195, USA; Seattle Spine & Sports Medicine, 3213 Eastlake Avenue East, Suite A, Seattle, WA 98102, USA.
Abstract:
Although most patients recover from acute whiplash injuries, those with chronic whiplash syndrome develop signs of central nervous system (CNS) amplification of pain and have a poor prognosis. In this context, specific pain generators from acute whiplash have been identified through clinical, biomechanical, and animal studies. This article gives a clinical perspective on current understanding of these pain generators, including the phenomenon of CNS sensitization.
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