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Dimer-on-mirror SERS substrates with attogram sensitivity fabricated by colloidal lithography.

Aron Hakonen¹, Mikael Svedendahl, Robin Ogier

¹Department of Applied Physics, Division of Bionanophotonics, Chalmers University of Technology, Gothenburg, Sweden. hakonen@chalmers.se kall@chalmers.se.

|May 9, 2015

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We developed a cost-effective method to create nanoplasmonic substrates for surface-enhanced Raman scattering (SERS) molecular analysis. These substrates achieve high sensitivity, enabling attogram-level detection of molecules.

Area of Science:

Plasmonics and Nanotechnology
Spectroscopy
Materials Science

Background:

Surface-enhanced Raman scattering (SERS) molecular analysis relies on nanoplasmonic substrates for enhanced field properties.
Large-scale, cost-effective production of these substrates remains a significant challenge for widespread SERS application.

Purpose of the Study:

To develop an inexpensive, scalable method for producing high-performance nanoplasmonic substrates.
To demonstrate the SERS capabilities of the fabricated gold nanostructures for sensitive molecular detection.

Main Methods:

Colloidal hole-mask lithography was employed as a facile, bottom-up technique.
Macroscopic dimer-on-mirror gold nanostructures were fabricated.
SERS performance was evaluated using 4-aminothiophenol (BPE) as a probe molecule.

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Main Results:

The fabricated nanostructures exhibited excellent SERS performance with a Raman enhancement factor of approximately 10^11.
Attogram levels (2.5 and 50 ag) of BPE were detected using Raman microscopy and a handheld device.
The results compare favorably with previously reported record performance values for SERS.

Conclusions:

Colloidal hole-mask lithography offers a scalable and cost-effective route to high-performance SERS substrates.
The developed nanoplasmonic substrates demonstrate significant potential for sensitive, large-scale molecular analysis.
This advancement could facilitate broader adoption of SERS in various analytical fields.