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Mechanism of anti-ulcer effect of calf blood extract
S Onodera1, K Takenaga, M Yoshinaga
1Ome Research Laboratories, Tobishi Pharmaceutical Co., Ltd., Ome-shi, Japan.
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1989
Abstract:
The mechanism of anti-ulcer effect of Solcoseryl, an extract from calf blood, was studied. Solcoseryl (10 ml/kg, i. v.) increased basal and chemically reduced potential difference of the gastric mucosa in rats. Solcoseryl (1-10 ml/kg, i.v.) also increased gastric mucosal blood flow and gastroduodenal HCO3- secretion. These results indicate that Solcoseryl has a mucosal protective effect which may contribute to the mechanism of its anti-ulcer effect.