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Corneal collagen crosslinking (CXL) increases corneal light scattering and retinal straylight, particularly in the central cornea. These CXL-induced changes did not correlate with improved visual acuity.

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Area of Science:

  • Ophthalmology
  • Corneal Science
  • Vision Science

Background:

  • Keratoconus is a progressive corneal ectasia.
  • Corneal collagen crosslinking (CXL) is a treatment to halt keratoconus progression.
  • The impact of CXL on corneal optical properties requires further investigation.

Purpose of the Study:

  • To evaluate changes in corneal straylight after CXL.
  • To assess the correlation between straylight, visual acuity, and corneal topography post-CXL.

Main Methods:

  • Retrospective study of 31 eyes undergoing CXL (Dresden protocol).
  • Corneal light scattering measured by densitometry (Scheimpflug tomography).
  • Retinal straylight measured (C-Quant); CDVA and topography recorded.

Main Results:

  • Corneal densitometry increased post-CXL, remaining elevated centrally after 12 months.
  • Retinal straylight peaked at 1 month, remaining elevated at 1 year.
  • Increased CDVA and reduced maximum keratometry observed; higher densitometry correlated with greater K reduction.

Conclusions:

  • CXL-induced stromal changes increase corneal densitometry, especially centrally.
  • Increased corneal densitometry correlates with elevated retinal straylight.
  • Postoperative CDVA did not correlate with these optical changes.