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Implant site Nexplanon reaction?

Célia Pedroso1, Isabel Martins2, Fátima Palma2

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A rare allergic reaction to barium sulfate in Nexplanon implants caused local symptoms. Implant removal successfully resolved the patient's condition, highlighting a rare but significant side effect.

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Area of Science:

  • Reproductive Medicine
  • Pharmacovigilance

Background:

  • Nexplanon is a long-acting reversible contraceptive implant releasing etonogestrel for 3-year contraception.
  • The implant contains barium sulfate for X-ray visibility, a component rarely associated with adverse reactions.

Observation:

  • A 39-year-old woman presented with a local reaction attributed to the barium sulfate within her Nexplanon implant.
  • Medical treatment did not alleviate symptoms; only surgical removal of the contraceptive device provided relief.

Findings:

  • The patient experienced complete symptom resolution within 72 hours post-implant removal.
  • This case represents one of only three documented instances of barium sulfate allergy linked to Nexplanon.

Implications:

  • Healthcare providers should consider barium sulfate allergy in patients experiencing unexplained local reactions to Nexplanon.
  • Further pharmacovigilance is warranted to understand the incidence and management of rare adverse events associated with contraceptive implants.