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Aging, glucocorticoids and developmental programming.

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Basal circulating corticosterone levels decline in the second half of life in rats. Maternal obesity exposure elevates corticosterone in offspring, but the age-related decline remains consistent.

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Area of Science:

  • Endocrinology
  • Aging Research
  • Developmental Biology

Background:

  • Glucocorticoids regulate vital physiological functions throughout life.
  • Conflicting data exists regarding glucocorticoid aging trajectories.
  • Limited life-course data on basal circulating glucocorticoids is available.

Purpose of the Study:

  • To profile basal circulating corticosterone across the rat life-course.
  • To investigate sex differences in corticosterone levels.
  • To determine if maternal obesity during development alters later-life corticosterone trajectories.

Main Methods:

  • Longitudinal study of basal circulating corticosterone in rats from weaning to aged phases (PND 21-850).
  • Analysis included control and offspring of obese mothers, assessing both sexes.
  • Five life-course time points were utilized for trajectory analysis.

Main Results:

  • A significant fall in corticosterone was observed between PND 450 and 650 in both sexes.
  • Females exhibited higher basal corticosterone concentrations than males.
  • Offspring of obese mothers showed elevated corticosterone levels, with a similar age-related decline pattern.

Conclusions:

  • Circulating corticosterone shows a decline in the second half of life in rats.
  • Maternal obesity may influence offspring lifespan via elevated corticosterone, though aging patterns persist.
  • This study provides crucial insights into normative and programmed aging of glucocorticoids.