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Contrasting genetic architectures in different mouse reference populations used for studying complex traits

David A Buchner1, Joseph H Nadeau2

  • 1Department of Genetics and Genome Sciences, Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA;

Genome Research
|May 9, 2015
PubMed
Summary

Chromosome Substitution Strains (CSSs) reveal complex genetic architectures with many quantitative trait loci (QTLs), while genome-wide association studies (GWAS) show fewer QTLs with smaller effects. Understanding these varied genetic architectures is crucial for complex trait and disease research.

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