Related Experiment Video
Updated: Apr 12, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
An Algorithm Using Twelve Properties of Antibiotics to Find the Recommended Antibiotics, as in CPGs
Background:
Clinical Decision Support Systems (CDSS) incorporating justifications, updating and adjustable recommendations can considerably improve the quality of healthcare. We propose a new approach to the design of CDSS for empiric antibiotic prescription, based on implementation of the deeper medical reasoning used by experts in the development of clinical practice guidelines (CPGs), to deduce the recommended antibiotics.
Methods:
We investigated two methods ("exclusion" versus "scoring") for reproducing this reasoning based on antibiotic properties.
Results:
The "exclusion" method reproduced expert reasoning the more accurately, retrieving the full list of recommended antibiotics for almost all clinical situations.
Discussion:
This approach has several advantages: (i) it provides convincing explanations for physicians; (ii) updating could easily be incorporated into the CDSS; (iii) it can provide recommendations for clinical situations missing from CPGs.
More Related Videos
09:59Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
Published on: July 21, 2023
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Related Concept Videos
Antibiotic Selection
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Automated Microbial Diagnostics
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Dosage Interval and Administration Route: Determination Methods
Clinical Significance of Antibiotic Resistance