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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis of the nakanishi ring-locked retinoid
Jamie B Côté1, Tan D Quach1, Andrey P Demenev2
1Dalton Medicinal Chemistry Inc., 349 Wildcat Road, Toronto, ON, Canada M3J 2S3.
Abstract:
An optimized synthetic route to prepare ring-locked retinoid 1a has been developed. We fully describe a purification protocol that provides isomerically pure 1a in support of on-going proof of concept studies for the development of therapeutic agents to treat human ADRP. Additionally, we have found that isomerically pure 1a can be stored in amber vials under argon at -20°C for use over time (up to six months) without degradation. Thus, enabling 1a to be an accessible and valuable biological tool.
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