Related Experiment Video
Updated: Apr 12, 2026
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
13.6K
Current updates on oxazolidinone and its significance
Neha Pandit1, Rajeev K Singla2, Birendra Shrivastava1
1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Jaipur National University, Jagatpura-Jaipur, Rajasthan 302025, India.
International Journal of Medicinal Chemistry
|May 9, 2015
Summary
Oxazolidinone, a five-member heterocyclic ring, shows promise for medicinal applications, particularly its antibacterial activity. This review consolidates current knowledge on its synthesis, mechanisms, properties, and research advancements.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- Oxazolidinone is a five-member heterocyclic ring with significant medicinal potential.
- It exhibits notable antibacterial activity, making it a target for drug development.
- Existing literature covers various facets of oxazolidinone chemistry and applications.
Purpose of the Study:
- To provide a comprehensive review of oxazolidinone.
- To consolidate information on synthetic methodologies.
- To summarize pharmacological actions, medicinal properties, and recent research.
Main Methods:
- Literature review of synthetic procedures for oxazolidinone.
- Analysis of pharmacological mechanisms of action.
- Compilation of medicinal properties and current research.
Main Results:
- Oxazolidinone possesses preferential antibacterial activity.
- Diverse synthetic routes have been reported for its preparation.
- The review covers its mechanism of action, medicinal value, and ongoing research.
Conclusions:
- Oxazolidinone is a valuable heterocyclic scaffold in medicinal chemistry.
- Further research into its synthesis and applications is warranted.
- This review serves as a central resource for understanding oxazolidinone's potential.
Related Concept Videos
01:28Inhibitors of Bacterial DNA Synthesis
77
Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These...
77
01:25Clinical Significance of Antibiotic Resistance
54
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
54
01:11Aryldiazonium Salts to Azo Dyes: Diazo Coupling
4.2K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para...
4.2K
01:25Inhibitors of Bacterial Protein Synthesis
66
Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
66
01:25Mechanism of Antibiotic Resistance in MRSA
132
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
132
01:30Development of Antibiotic Resistance
2.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K