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Brain and Lung Abscesses in a 48-year-old Man with Focal and Segmental Glomerulosclerosis
Ali Momeni1, Fereidoon Rahmani2, Hamid Nasri3
1Nephrologist, Department of Nephrology, Shahrekord University of Medical Sciences , Shahrekord, Iran .
Abstract:
Focal segmental sclerosis (FSGS) is a common cause of idiopathic nephrotic syndrome in the adult population. A patient aged 48- year-old was admitted for evaluation of azotemia. Renal biopsy showed tip lesion FSGS and acute tubular necrosis. After methyl prednisolone pulse therapy, partial remission occurred, and he was stable with oral prednisolone and cyclosporine. Few months later two serious complications including lung and brain abscess occurred. We describe a case of FSGS with lung and brain abscess, who responded to medical management.
Insights
Focal segmental sclerosis (FSGS) can lead to serious complications like lung and brain abscesses. This case study shows a patient with FSGS who successfully responded to medical treatment for these severe infections.
Area of Science:
- Nephrology
- Infectious Disease
Background:
- Focal segmental glomerulosclerosis (FSGS) is a primary cause of nephrotic syndrome in adults.
- Azotemia prompted evaluation, revealing FSGS with acute tubular necrosis on renal biopsy.
Observation:
- The patient, aged 48, received methylprednisolone pulse therapy, achieving partial remission.
- Maintenance therapy included oral prednisolone and cyclosporine.
- Subsequently, the patient developed severe complications: lung and brain abscesses.
Findings:
- The case highlights a rare occurrence of FSGS complicated by disseminated infections.
- Successful medical management of both FSGS and the abscesses was achieved.
Implications:
- This case underscores the importance of vigilant monitoring for infections in immunosuppressed FSGS patients.
- It suggests that aggressive medical management can be effective for FSGS with severe infectious complications.
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