Cronkhite-Canada Syndrome (CCS)-A Rare Case Report

Area of Science:

• Gastroenterology
• Dermatology
• Genetics

Background:

• Cronkhite-Canada syndrome (CCS) is an exceedingly rare, non-inherited disorder.
• It is characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss, and diarrhea.
• The suspected etiology involves an autoimmune process.

Observation:

• This report presents a case of CCS in an elderly Indian male.
• The diagnosis was established through a combination of patient history, physical examination, endoscopic findings, and histological analysis.

Findings:

• The case highlights the diverse clinical presentation of Cronkhite-Canada syndrome.
• It adds to the limited global case reports, with approximately 450 documented worldwide.

Implications:

• This case report expands the understanding of CCS demographics and geographical distribution.
• It underscores the importance of considering CCS in the differential diagnosis of patients presenting with similar gastrointestinal and dermatological symptoms.
• Further research into the autoimmune basis of CCS may reveal novel therapeutic targets.